J Am Vet Med Assoc. 1980 Jun 15;176(12):1353-4.
Efficacy of albendazole for prevention of fascioliasis in sheep.

Rew RS, Knight RA.

Daily doses of albendazole administered as a premix in the feed for 35 days were effective in preventing Fasciola hepatica infections in 17 sheep in three groups: 5 mg/kg/day (6 sheep) was 100% effective; 3 mg/kg/day (5 sheep) was 98% effective; and 1 mg/kg/day (6 sheep) was 42% effective. Infective cysts were given daily for 5 days during the first week of treatment, treatment was continued an additional 28 days, and sheep were necropsied 14 weeks after final cyst inoculation. There were no visible lesions in any livers of sheep given albendazole at the rate of 5 mg/kg/day or in three of five livers of sheep dosed at the rate of 3 mg/kg/day. Sheep treated with albendazole had a mean weight gain of 2.7 kg, 4.0 kg, and 4.0 kg greater than the controls for the dosages of 1, 3, and 5 mg/kg/day, respectively. Determination of bile duct damage by measurement of serum gamma-glutamyl transpeptidase activity at 9 weeks after final cyst inoculation revealed increases of 3.0X, 1.0X, and 1.1X for the dosages of 1, 3, and 5 mg/kg/day, respectively, and 2.3X for the control, as compared with 7 weeks after final cyst inoculation.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6107285&dopt=Abstract albendazole Albenza




Lancet. 1983 Sep 17;2(8351):652-6.
Albendazole as a potential treatment for human hydatidosis.

Saimot AG, Meulemans A, Cremieux AC, Giovanangeli MD, Hay JM, Delaitre B, Coulaud JP.

The pharmacokinetics of albendazole was evaluated in 11 patients with hydatid disease who underwent surgery 12 h after the last dose of drug. Albendazole and its main metabolite, albendazole-sulphoxide, were assayed in the serum from peripheral and portal blood, the liver, bile, lungs, and hydatid cyst walls and fluid. After a 10-14 mg/kg daily oral dose of albendazole, concentrations of 1844 +/- 904 ng/g wet tissue of albendazole-sulphoxide were found in the liver and 749 +/- 34 ng/g wet tissue in the lungs. The level in hydatid cyst fluid was 921 +/- 314 ng/ml. The drug was also excreted through the bile. The same daily oral dose produced very stable blood levels after 2 to 4 days of treatment (600-1000 ng/ml). In another part of the study 3 patients with liver cysts, 2 with peritoneal cysts, and 5 with bone cysts received 7 mg/kg twice a day prophylactically and/or therapeutically for 30 days. In all cases the treatment was repeated several times after intervals of 2 weeks. The 3 patients with liver cysts were cured (probably due to treatment); there was no recurrence in the 2 patients with peritoneal cysts and very slight improvement in the 5 cases with bone cysts. The drug was clinically and biologically extremely well tolerated.

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Am J Trop Med Hyg. 1983 Sep;32(5):984-9.
Albendazole, an effective single dose, broad spectrum anthelmintic drug.

Ramalingam S, Sinniah B, Krishnan U.

Albendazole, a new anthelmintic drug was evaluated in Malaysia in 91 patients, with single or mixed infections of Ascaris, Trichuris, and hookworm. Albendazole was administered as a single dose of 400 mg, 600 mg, or 800 mg. The cure rate for Ascaris at all three doses was 100% at days 14 and 21 post-treatment; for hookworm it was 98.8%, 100% and 98%, respectively, at day 14 and 68.8%, 100% and 84%, respectively, at day 21; for Trichuris it was 31.2%, 57.1% and 42.3%, respectively, at day 14 and 27.3%, 60.9% and 48.0%, respectively, at day 21. The egg reduction rate at day 21 was 100% at all three doses for Ascaris, 94.5%, 100% and 96.1%, respectively, for hookworm; and 39.2%, 85.1% and 72.8%, respectively, for Trichuris. There were no side effects, and biochemical examination of blood and urine did not indicate any unfavourable changes. Based on this trial, the recommended dosage for Ascaris and hookworm is a 400 mg single dose, and for Trichuris is a 600 mg single dose. Albendazole appears to be more effective than other available anthelmintic drugs.

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Am J Vet Res. 1978 Jun;39(6):1027-31.
Albendazole therapy for experimentally induced Paragonimus kellicotti infection in cats.

Dubey JP, Hoover EA, Stromberg PC, Toussant MJ.

The effect of albendazole therapy was studied in 6 cats with pulmonary paragonimiasis induced by experimental inoculation of metacercariae (25/cat) of Paragonimus kellicotti. At 76 to 101 days after they were inoculated, 5 cats were administered an oral aqueous suspension of albendazole in 2 divided doses totaling 20 mg (2 cats), 50 mg (1 cat), or 100 mg (2 cats)/kg of body weight each day for 14 to 21 days. The 6th cat (control) was not administered albendazole. Nine days after cats were given the 50- and 100-mg/kg dosages, Paragonimus ova were not seen in the feces of 3 cats. There was marked reduction in ova production in the feces of the 2 cats administered 20 mg/kg of albendazole. Live flukes were not recovered from the lungs of 3 cats necropsied 4 or 5 weeks after dosing with 50 or 100 mg/kg, but the lungs of the 2 cats administered 20 mg of albendazole/kg yielded 9 and 7 apparently viable flukes. Seventeen live flukes were recovered from the control cat not treated with albendazole. In 4 noninoculated normal cats administered 20 mg (1 cat), 100 mg (1 cat), and 200 mg (2 cats) of albendazole/kg of body weight each day for 14 days, there were no gross or microscopic lesions attributable to the drug.

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Am J Vet Res. 1984 Jan;45(1):80-2.
Efficacy of albendazole against Fascioloides magna in sheep.

Stromberg BE, Schlotthauer JC, Conboy GA.

Sheep experimentally infected with Fascioloides magna were used in a controlled study to determine the flukicide activity of different doses of albendazole (methyl [5(propylthio)-1H-benzimidazol-2-yl] carbamate). Sheep, about 4 months old, were inoculated with 100 metacercariae of F magna and treated with the various doses of albendazole 10 weeks later. At 6 weeks after treatment, the sheep were necropsied, flukes were recovered and measured, and the pathologic changes were recorded. The sheep were given different doses of albendazole (5, 7.5 [single dose or double dose], 10, and 15 mg/kg) and were compared with both nontreated inoculated and nontreated noninoculated controls. There were up to 70% fewer worms recovered in the group given 2 doses of 7.5 mg/kg than there were in the nontreated controls. There was also a significant reduction in flukes recovered in the groups given the 7.5, 10, and 15 mg/kg doses. Because a single F magna fluke has the potential to kill a sheep, it is imperative to consider the number of sheep with no flukes after treatment. According to that criterion, 50% of the sheep were protected at dose rates of 7.5 (single dose, double dose), 10, and 15 mg/kg of body weight.

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J Pharm Biomed Anal. 2003 Jun 1;32(2):337-43.
Analysis of albendazole metabolites by electrospray LC-MS/MS as a probe to elucidate electro-oxidation mechanism of albendazole.

de Lima RG, Bonato PS, da Silva RS.

Departamento de Quimica, Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, USP, Av. dos Bandeirantes, 3900, 14040-901, Ribeirao Preto, Sao Paulo, Brazil.

The electrochemical oxidation of albendazole was accomplished by controlled potential electrolysis technique. The oxidation was carried out in different pH solutions and yields the same products obtained by in vivo and in vitro metabolism, i.e. albendazole sulfoxide and albendazole sulfone. The identification of albendazole oxidation products was carried out by LC-MS/MS.

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Tijdschr Diergeneeskd. 1982 Oct 1;107(19):731-6.
[Effect of albendazole and cambendazole on the egg output of Strongylidae in horses]

[Article in Dutch]

Mirck MH, van Meurs GK.

The anthelmintic activity of albendazole (5 mg/kg) and cambendazole (20 mg/kg) was compared in twenty-two naturally infected horses and ponies, which were divided into two equal groups. Comparison was based on the faecal strongyle egg counts. On the fourteenth and twenty-eighth days after the first treatment in May, the reductions in faecal egg counts were 99.1 and 93.9 per cent respectively in the albendazole group and 88.0 and 75.7 per cent respectively in the cambendazole group. Within fourty-two days after treatment had been initiated, the mean EPG (eggs per gram) had been restored to the initial level in both groups. The same animals were treated again in August; this time, however, the anthelmintics were changed. In the albendazole group, the faecal egg counts were reduced by more than 95 per cent and, in the cambendazole group, by not more than 84.1 per cent. As the horses were not weighed, the disappointing results obtained with camendazole may have been due to low a dosage, although resistance cannot be ruled out. When the trial was concluded in October, within fifty-six days after treatment in August, the faecal egg counts continued to be remarkably low in both groups: 8.3 per cent of the average EPG prior to treatment in the albendazole group and 21.2 per cent in the cambendazole group. As the trials did not provide any evidence to suggest a larvicidal action of the two anthelmintics, the difference with the results of treatment in May is attributable to an inhibitory effect on the development of the infective Strongyle larvae, specifically Cyathostominae, ingested during the summer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7147218&dopt=Abstract albendazole Albenza