Vermox
The pharmacokinetics and bioavailability of mebendazole in man: a pilot study using [3H]-mebendazole.

Dawson M, Allan RJ, Watson TR.

Following the intravenous administration of a tracer dose (1.7 microgram) of [3H]-mebendazole to a man, an elimination half-life of 1.16 h was observed and the volume of distribution was calculated to be 2.03 l/kg. After oral administration of the same dose, an elimination half-life of 0.74 h was observed. The bioavailability of mebendazole from the solution was found to be 17%.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7126419&dopt=Abstract mebendazole Vermox



Vermox
Observations on mebendazole vs. thiabendazole in the treatment of human trichinellosis.

Horstmann RD, Kern P, Volkmer KJ, Dietrich M.

Six patients with acute trichinellosis were studied. Three patients were treated with mebendazole and the other three with thiabendazole. Both drugs were given at a daily dose of 50 mg per kg body weight for seven consecutive days. No substantial differences were evident in the efficacy of the two drugs when symptoms, clinical findings, and laboratory data were followed for three months. However, mebendazole was better tolerated than thiabendazole. The diagnosis was based on epidemiological data and positive antibody tests. In two cases, diagnosis was confirmed by isolation of trichinella larvae from 10 ml blood samples filtered through polycarbonate membranes.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7135477&dopt=Abstract mebendazole Vermox



Vermox
Inhibition of acetylcholinesterase secretion from Nippostrongylus brasiliensis by benzimidazole anthelmintics.

Watts SD, Rapson EB, Atkins AM, Lee DL.

Treatment of rats infected with Nippostrongylus brasiliensis with a single, oral therapeutic dose of the anthelmintic benzimidazole carbamates oxfendazole or mebendazole resulted, 24 hr later, in a marked reduction (60-90%) in the secretion of a low molecular weight acetylcholinesterase from the parasites when they were incubated in vitro. This effect coincided with the expulsion of parasites from the host as a result of the therapy. When parasites were incubated in vitro with 0.1 mM oxfendazole, mebendazole, flubendazole, parbendazole, cambendazole or thiabendazole a similar effect was observed; with oxfendazole and mebendazole the effect was apparent within 1 hr and lasted for at least 4 hr after removal to fresh, drug-free medium. Whether treated in the host or in vitro the reduction in secretion was balanced by an equivalent rise in acetylcholinesterase activity within the parasites. It is suggested that the inhibition of protein secretion may be a specific manifestation of a general effect of these compounds on microtubule function.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7150334&dopt=Abstract mebendazole Vermox



Vermox
Chemotherapy and chemoprophylaxis of Angiostrongylus malaysiensis infection in rats with levamisole and mebendazole.

Ambu S, Kwa BH, Mak JW, Singh KI.

The chemoprophylactic and chemotherapeutic effects of levamisole and mebendazole on Angiostrongylus malaysiensis infection in rats were studied. Both drugs were ineffective in preventing infection while the post-infection treatment showed 100% efficacy. Furthermore, levamisole and mebendazole when given in combination appeared to have an antagonistic effect.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7160790&dopt=Abstract mebendazole Vermox



Vermox
Preoperative treatment of hydatid cysts with mebendazole.

Ronconi P, Borzone A, Alquati P, Pittiruti M.

Mebendazole--an anthelmintic drug which is known to have a lethal effect on hydatid cysts--was administered preoperatively to patients affected by Echinococciasis, in order to sterilize cysts and prevent surgical contamination. Our results suggest that mebendazole treatment (1500 mg/die for 25 days) was effective in ten out of eleven cases; no major toxic effect was observed.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7183592&dopt=Abstract mebendazole Vermox



Vermox
A survey for intestinal helminths in recently wild-caught Macaca mulatta and results of treatment with mebendazole and thiabendazole.

Karr SL Jr, Henrickson RV, Else JG.

One hundred Macaca mulatta, trapped in India and transported directly to the California Primate Research Center, were surveyed for the prevalence of gastrointestinal helminths. Trichostrongylus sp. was found in 86% of the animals, followed by Strongyloides fulleborni (63%), Streptopharagus sp. (38%), Oesophagostomum sp. (23%) and Anatrichosoma sp. (21%). Treatment with mebendazole and thiabendazole was efficacious against all the intestinal nematodes, with the exception of mebendazole versus Streptopharagus sp.

Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7191904&dopt=Abstract mebendazole Vermox