References: Laxative
Dig Dis Sci. 1987 Mar;32(3):267-71.
Factors affecting methane production in humans. Gastrointestinal diseases and alterations of colonic flora.
Peled Y, Weinberg D, Hallak A, Gilat T.
Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) and 11 of 32 patients with the irritable bowel syndrome (34.4%). Breath methane is thus unusual in Crohn's disease. After bowel cleansing for colonoscopy or surgery, 15 of 18 methane producers became nonproducers, whereas after antibiotic treatment, 24 of 30 producers sustained their methane-producing status. After gentamycin and cephazolin therapy, methane production was abolished in three of eight patients. Slight spontaneous variations in methane production were also noticed with two of 23 control subjects, becoming nonproducers on restudy after 10-25 months. Thus gastrointestinal diseases, bowel cleansing and, to a much lesser degree, antibiotic therapy, affect methane production.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3816480&dopt=Abstract constipation laxative colon cleansing
Scand J Gastroenterol. 1985 Apr;20(3):351-5.
Epidemiology of polyps in the rectum and sigmoid colon. Design of a population screening study.
Hoff G, Vatn M, Gjone E, Larsen S, Sauar J.
The design of a population screening study, including endoscopic screening for polyps in the rectum and sigmoid colon, was tested in a defined population sample of 200 women and 200 men aged 50-59 years. The attendance rate was 81%. A simple bowel cleansing procedure performed immediately before the examination gave satisfactory conditions for endoscopic examination in 94% of attendants. Polyp prevalence was 35%. The present material and results represent the basis for further follow-up studies of risk factors for the development of cancer in the same group of individuals.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4001844&dopt=Abstract constipation laxative colon cleansing
Int J Clin Pharmacol Res. 1985;5(3):181-3.
Chemoprophylaxis of postoperative infections in colorectal surgery.
Rakovec S, Gubina M.
Colorectal surgery involves a high risk of postoperative infections. The major risk factors can be reduced by appropriate preparation of the patient for the operation. Mechanical removal of gross faecal material from the bowel, possible before most elective operations, does not sufficiently reduce the incidence of postoperative infections. Prophylactic medication has not yet been widely accepted, although its effectiveness has been confirmed by a number of studies. Preoperative management of patients subjected to colorectal surgery at our institution in the last three years, consisted of mechanical cleansing of the intestinal tract for two days, followed by rapid intravenous administration of gentamicin 80 mg and metronidazole 500 mg in a single dose, 30 min to 1 h before the operation. From 1971 to 1973, the postoperative infection rate in 432 patients submitted to elective colorectal surgery was 29%. During the period 1981-1983, operations of the same kind were performed in 572 patients, the infection rate being 15%. Prophylactic single-dose administration of gentamicin in combination with metronidazole has proved to be very effective in reducing postoperative infections.
Laxative online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4018952&dopt=Abstract constipation laxative colon cleansing
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